Zantac Carcinogen: What Is Ndma
NDMA can also be formed during the cooking of foods, especially food such as cured meats and fish because they contain sodium nitrite as a preservative. It is also found in:
- Tobacco smoke
Preliminary testing by the FDA shows some samples of Zantac and ranitidine contain higher levels of NDMA than food.
Although human studies are limited, NDMA is listed as a probable carcinogen to both animals and humans. It is still unknown how ranitidine was contaminated with NDMA, as found in laboratory tests.
There is a possibility that ranitidine is unstable and breaks down on its own to form NDMA. The FDA-approved acceptable amount of NDMA intake is 96 nanograms per day. Studies have shown that when ranitidine mixes with the gastric fluid and sodium nitrites that stimulate the digestion process, high amounts of NDMA are produced. Exposure to simulated stomach conditions caused ranitidine to produce approximately 304,500 ng of NDMA per tablet.
It is also possible that generic versions of Zantac are contaminated with NDMA when manufactured in other countries without strict quality control standards.
The Food and Drug Administration reports that its independent testing has shown that the heartburn medications Pepcid, Tagamet, Nexium, Prevacid, and Prilosec do not contain the chemical NDMA.
Does Zantac 360 Have This Cancer Risk
Thankfully, Zantac 360 does not carry this potential cancer risk. After discovering NDMA in ranitidine, the FDA requested other H2 blockers be tested for the carcinogen. They found famotidine had no NDMA in it at all. Because it is free of this chemical, there is no current concern of a possible link to cancer.
When Did Zantac Become Available
The FDA first approved ranitidine in 1981. The FDA has updated the drugs warning labels twice in the past six years due to new scientific evidence linking Zantac and other acid-reducing drugs with a rare form of liver cancer.
Since then, the FDA has updated Zantacs drug warning label to include a precaution about the increased risk of developing stomach cancer.
In addition, the warming extends to all generic medications containing ranitidine.
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What Is Zantac And How Is It Used
Zantac is often referred to by the medical term Ranitidine. It is prescribed to alleviate throat, stomach, and general gastrointestinal tract problems.
It normally addresses heartburn, ulcers, gastroesophageal reflux disease or GERD, indigestion, stomach discomfort, excessive coughing, trouble swallowing, and related problems.
Zantac is most effective any time there is substantial acid buildup. It is called an H2 blocker. Doctors recommended Zantac to reduce acid.
They stopped those recommendations after the United States drug administration FDA recommended not taking any brand name or generic ranitidine drugs due to probable human carcinogen links.
How exactly does Zantac work, and how is it supposed to stop gastroesophageal reflux disease? Zantac and generic drugs try to lower the amount of acid your stomach makes and distributes in your body. That is why they are called H2 blockers. They also are used to treat recurring problems like coughing, difficulty swallowing, and other stuff.
Yet, per the United States drug administration FDA, Zantac products and generic drugs may cause cancer due to high levels of NDMA . Sloan Kettering and other cancer centers continue to investigate what cancer Zantac causes and other cancer- problems associated with taking Zantac ranitidine.
Antacid Lawsuit Gastrointestinal Cancer From Nexium Or Prilosec
If you developed stomach cancer, esophageal cancer, or liver cancer after taking Nexium, Prilosec, Prevacid, or a prescription antacid, contact our lawyers today for a free, confidential consultation. Several medical studies have linked these drugs, called proton-pump inhibitors, to an increased risk of gastrointestinal cancer. This page answers several frequently asked questions about filing an antacid cancer lawsuit.
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Types Of Zantac Lawsuits
Although many people who have filed a Zantac lawsuit have done so due to developing cancer after taking the drug, this is not true for everyone.
If you took prescription Zantac for an extensive amount of time and havent been diagnosed with cancer, you may still be eligible to file a Zantac class action lawsuit to recover compensation for the money you spent on the heartburn drug. If you took Zantac and experienced health issues other than cancer, you may be able to file a Zantac personal injury claim.
Understanding the difference between the types of lawsuits can help those who have been harmed by the drugs dangerous effects seek the compensation they deserve and know which claim makes sense for their individual situation.
Ndma And Ranitidine Cancer Link
If you have been taking Zantac or any other drugs containing ranitidine, you might worry about the cancer-causing chemical NDMA in these drugs. Drugs containing carcinogenic chemicals have the potential to cause cancers and other illnesses and injuries to those who take them.
According to Harvard Medical School, NDMA is an environmental contaminant that can be found in water and a variety of foods, for example, vegetables, dairy products, and meat.
Studies regarding the effects of exposure to NDMA are still ongoing, and studies in humans are limited. According to the Centers for Disease Control and Prevention , studies on animals linked NDMA to liver cancer and lung cancer, along with non-cancerous diseases like liver disease.
For a free legal consultation with a What Is the Safest Antacid? Lawyer serving nationwide, call
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How Can A Lawyer Help With Your Zantac Case
Zantac was a widely used drug before the FDA sounded the alarm on NDMA exposure . As a result, many people wonder if they can file a claim for resulting harm and damage.
In that pursuit of justice and compensation, it might behoove you to engage counsel to aid in those efforts. An experienced attorney can expedite the process and craft a Zantac case strategy from start to finish.
Here is a specific list of action items a legal team can accomplish for you and your family:
- Research FDA pronouncements on Zantac, NDMA, ranitidine, and drug quality control standards.
- Compare this medication to similar drugs, including those with a history of litigation.
- Investigate the factual circumstances that led to your illness and draft a Zantac case for relief and compensation.
- Present a case at trial or lead negotiations in a settlement.
One issue you may have in an injury lawsuit is tying the use of Zantac to cancer you have developed. A necessary element of every personal injury lawsuit is that you prove causation, namely that you would not have been injured had it not been for the defendants actions.
It is not always easy to tie your case of cancer to defective heartburn medications. We will go through your medical records and work with expert witnesses to help you show causation. It may be a problem that individual plaintiffs may have in the early Zantac cases.
Need A Safe Antacid For Heartburn Fda Declares Pepcid Nexium And Others Free Of Ndma
The bad news for heartburn sufferers, of course, is that Zantac and its ranitidine generics have, perhaps for years, contained a suspected carcinogen without the FDA knowing it. The good news is that the FDA has now declared a handful of branded antacid alternatives and their generics as safe for consumers.
The FDA Wednesday said that preliminary tests of alternatives including Pepcid , Tagamet , Nexium , Prevacid and Prilosec found no N-nitrosodimethylamine , the suspected cancer-causing agent found in OTC ranitidine drugs including the popular Zantac.
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What Are The Chances Of Getting Cancer
So far, there is only limited evidence that NDMA in ranitidine causes cancer, and scientists havent come up with an absolute risk value.
A study under review conducted by researchers at Memorial Sloan Kettering Cancer Center found an increased risk in the odds of developing certain cancers, according to a 2020 article by Richard H. Adamson and Bruce A. Chabner in The Oncologist.
The European Medicines Agency estimated that the cancer risk for valsartan, another medication contaminated with NDMA, ranges from 12 to almost 30 cases per 100,000 people for those taking 320 mg of valsartan with 3.7 micrograms of NDEA and 24.1 micrograms of NDMA every day for four years, according to Adamson and Chabner.
NDMA contamination poses a potential carcinogenic risk of undetermined effect at present for those taking ranitidine, valsartan, or related medications on a regular basis.
Does Zantac Cause Cancer
Zantac contaminated with NDMA, a cancer-causing chemical, has been linked to cancer. Types of cancer caused by Zantac include bladder cancer, colon cancer and prostate cancer. In April 2020, Zantac products were withdrawn from the market because of the potential cancer risk.
Board-certified physicians medically review Drugwatch content to ensure its accuracy and quality.
Drugwatch partners with Physicians Review Network Inc. to enlist specialists. PRN is a nationally recognized leader in providing independent medical reviews.
Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry.
So far, there are over 500 federal Zantac lawsuits filed in Florida federal court against the makers of the anti-acid drug. These lawsuits claim Zantac caused several types of cancer and drug makers failed to warn the public.
Unfortunately, the science regarding Zantac made with ranitidine and cancer in humans hasnt shown a definitive answer.
Concerns over Zantacs link to cancer stem from a potential connection between ranitidine and its ability to form NDMA. Some studies as far back as the 1980s hinted at a link between the drug and NDMA formation. But one study that looked at the records of 65 million people found people who took ranitidine had less of a cancer risk than those who took another H2 blocker, famotidine.
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What Should Ppi Patients Do
So, should a patient who is on PPIs stop taking them? The answer is not always simple. Dr. Perre suggests patients who have been on PPIs consult their doctor about their prescription. But, he advises, patients should not stop taking PPIs cold turkey. Often, people have rebound symptoms after cutting them off abruptly, he says. Patients with GERD may be able to remain off PPIs if they modify their diet and lifestyle by, for example, not smoking, reducing alcohol and caffeine, avoiding spicy foods and not eating late at night. Its clear that lifestyle and diet modification should be the base of the pyramid with any treatment of a patient with acid reflux, Dr. Perre says. But in some people where that doesnt work, they may need to be on proton pump inhibitor therapy long term.” In the end, though, whether to continue taking the drugs should be a decision made in consultation with your doctor. Patients should talk to their doctors about long-term PPI use and follow their recommendations on whether to stay on the drugs or use another intervention.
Other Drugs Need Closer Investigation
The bodys ability to create NDMA after taking ranitidine seems limited. But the fact that NDMA can be generated as ranitidine sits on the shelf or medicine cabinet is still concerning, and this same phenomenon might occur in other drugs as well.
In another study, investigators added chloramine, a disinfectant routinely added to sterilize drinking water, to water samples that contained one of several medications that are structurally similar to ranitidine. They found that several commonly used drugs, including antihistamines , a migraine drug , another heartburn drug and a blood pressure drug all generated NDMA.
It is unclear whether the amount of NDMA created by these drugs when stored in hot and humid environments is dangerous, as with ranitidine. I believe that more studies need to be done right away to find out. It is always better to be safe than sorry, particularly when dealing with a possible carcinogen.
Editors note: This is an updated version of an article originally published on February 4, 2021.
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What We Know About The Possible Carcinogen Found In Zantac
The popular heartburn drug may produce potentially unsafe levels of NDMA when its active ingredient breaks down
French drugmaker Sanofi recently announced a recall of over-the-counter Zantac, the widely used acid reflux medication, in the U.S. and Canada over concerns of possible contamination from a probable carcinogen. This action followed recalls by manufacturers and retailers of generic versions of the drug, called ranitidine. The recalls have prompted questions about whether the drugs levels of a chemical called N-nitrosodimethylamine which has been linked to cancer in animalspose a more serious health risk than initially reported.
Several blood pressure medications, including the angiotensin receptor II blockers valsartan, losartan and irbesartan, were recalled last year over NDMA contamination. The U.S. Food and Drug Administration first flagged the possible contamination of ranitidine products this September. At that time, the FDA said the NDMA levels found in preliminary tests barely exceed amounts you might expect to find in common foods. But the agency released a statement on Oct. 2 calling the levels unacceptable. Asked to elaborate, FDA spokesperson Jeremy Kahn says, Although the FDA has detected NDMA in limited ranitidine samples at low levels, these levels still exceed what FDA considers acceptable for these products.
Tracing the Risks
A Complex Chemistry
Why Has Zantac Been Recalled
In a broad sense, the ultimate purpose of any product recall is to help improve consumer safety by removing the products from shelves. In this case, the recall serves to reduce the risk of exposure to cancer-causing substances found in Zantac and ranitidine. For this reason, you should immediately cease any Zantac consumption, and report any retailers who are still selling or distributing Zantac or any other dangerous drugs.
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Popular Heartburn Medication Zantac Found To Cause Deadly Cancer & Avenatti Facing More Trouble
Via Americas Lawyer: Mike Papantonio is joined by attorney Daniel Nigh to update us on litigation against manufacturers of the popular heartburn relief aid Zantac. The drug has been found to create sky-high doses of the carcinogen NDMA in the human body leading to stomach, bladder, and kidney cancers. Just WHY has it taken the FDA decades to alert the public about the dangers of this chemical, which is specifically used by researchers to foster cancer in lab animals? It appears celebrity attorney Michael Avenatti will be unable to escape the litany of charges against him, including for wire fraud, embezzlement, and extortion against Nike. Mike Papantonio explains more.
*This transcript was generated by a third-party transcription software company, so please excuse any typos.
Mike Papantonio: Researchers at Valisure discovered that Zantac, the popular heartburn medication, is loaded with a cancer causing substance known as NDMA. They first notified the FDA about this in June of last year, but just in keeping with the FDA, they did nothing about it. The FDA slept on this issue and now its killing Americans. Joining me to talk about this is Daniel Nigh. Daniel, lets start at the top. Whats the Zantac problem?
Mike Papantonio: Okay, put it in perspective. Were not talking about small amounts, as you point out, this is a chemical that when a scientist wants to make an animal, induce cancer in an animal, this is their go to chemical.
Daniel Nigh: Thats right.
Upper Or Middle Belly/back Pain
Abdominal pain is a common symptom of pancreatic cancer, as tumors that have grown fairly large start pressing on adjacent organs, causing discomfort and pain.
Its also common for these cancers to cause pain in the patients back, usually as a result of spreading to nerves surrounding the pancreas.
However, back and belly pain may also indicate other conditions besides pancreatic cancer, so its important to speak with your doctor if youre experiencing pain.
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Acid Reflux May Be Tied To Spike In Lethal Esophageal Adenocarcinoma
by Stephen Perrine, AARP Bulletin, June 2018
Many people dont realize that common heartburn symptoms can both lead to and mask something more serious.
One out of 5 Americans experience heartburn or acid reflux on a weekly basis 40 percent of us deal with it at least once a month. In many cases, we just blame the hot sauce and take an over-the-counter medicine to remedy it. Perhaps its time to think differently.
Esophageal adenocarcinoma cancer of the lining of the soft tube that delivers food and drink from the mouth to the stomach has increased sevenfold since the early 1970s, says Paul Oberstein, director of the gastrointestinal medical oncology program at NYU Langones Perlmutter Cancer Center in Manhattan. The American Cancer Society estimates that 15,850 Americans will die of esophageal cancer this year. Eighty-five percent of esophageal cancers are found in people 55 and older roughly four times as many men get the disease as women.
Its one of the fastest-growing issues we have in our population, says David Odell, assistant professor at Northwestern University Feinberg School of Medicine, thoracic surgeon at Northwestern Memorial Hospital and lead investigator on a study of esophageal cancer funded by the American Cancer Society.
Bottom line, says Odell: If you have reflux, discuss it with your physician to make sure theres nothing else going on. And if you have difficulty swallowing, see your doctor immediately it could be the first sign of a tumor.
Us Pharmaceuticals Not Required To Label Drug Sourcing
To make matters worse, the large majority of APIs are made in factories in China and India. U.S. pharmaceutical companies are not obligated to let American consumers know their drugs are being sourced from foreign countries.
The FDA does a poor job of checking these drugs. In fact, less than 1% of drugs are tested for impurities before they come into the U.S. Inspection of overseas factories by the FDA is in sharp decline. Despite opening three offices in China over a decade ago and vowing increased monitoring, only the Beijing office is still open.
Meanwhile, the FDA says it, along with other world regulators, is considering requiring new testing during the manufacturing process to reduce contamination of drugs. According to Reuters, spokesperson Janet Woodcock, the director of the FDAs Center for Drug Evaluation and Research, said that the FDA is simply going to have to be more vigilant: I think youll see tests added at the appropriate point during the manufacturing.
Jacqueline is a rocket scientist turned writer. She covers health, science and tech news for Citizen Truth. In her first career, she managed experiments & data on the Space Station & Shuttle.
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